Abstract
The effects of dimethyldithiocarbamate, disulfiram (tetraethylthiuram disulfide), diethyldithiocarbamate and ethyldithiocarbamate on dopamine-ß-hydroxylase activity in vivo were determined. Dimethyldithiocarbamate and disulfiram inhibited the conversion of dopamine- 14C to norepinephrine- 14C in the heart and adrenals of the rat and hamster. Diethyldithiocarbamate and ethyldithiocarbamate did not appear to inhibit the enzyme in the hamster heart, but did in the hamster adrenals and rat heart and adrenals.
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