Abstract
A patient was reported with suspected acute post-transfusion hepatitis C virus (HCV) infection, 5 months after the transfusion of 2 units of red cells. The archived serum samples of the two implicated donations were retested by the original 3rd-generation assay together with another 3rd-generation assay and RI-BA III, and were tested for HCV RNA using the PCR. Both donations were anti-HCV negative but one was found to be PCR positive. This donor was a regular donor and was identified as the husband of a donor identified 18 months earlier as being HCV positive. This case is an example of transmission of HCV in the window period of infection, and a probable example of the transmission of HCV from wife to husband through intimate contact.
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