Abstract
Donor-specific transfusions (DSTs) using stored and fresh blood were investigated in a rat heart allograft model. Lewis rats were recipients of preoperative DSTs and cardiac allografts from ACI donors. Blood was stored for 0, 1, 2, 3, 4, and 5 weeks prior to transfusion. Allograft survival and recipient sensitization were recorded. In all DST groups, allograft survival was superior to nontransfused controls ( P < 0.05). Stored blood was equal or better than fresh blood, and a 2-week storage was optimal ( P < 0.05). Storage of 2 weeks or greater resulted in decreased sensitization compared to storage for 1 week or less ( P < 0.05). This study supports the use of stored blood to enhance allograft survival and reduce recipient sensitization.
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