Donor selection in pre-sensitized patients for renal transplant

Sr Kankonkar

doi:10.15761/ccsr.1000118

Abstract

Donor selection in pre-sensitized patients for renal transplant

Highlights

The reactivity between HLA antigen of donor and ant-HLA antibody of recipient in pre-transplant assessment is one of the critical factors to determining successful transplantation, especially in renal Tx [1].Chronic rejection is a major threat to long term survival of an organ allograft It is presumed that such a rejection is mediated by the Abs development against antigens of allograft and has been observed that the long-term survival of renal allograft is significantly lower in patients who developed anti HLA antibodies following Tx than in patient that do not develop antibodies.An acute rejection occurs more often in pts who have been sensitized to HLA antigens by a previous Tx
12-year-old ESRD female patient with H/O SLE. She was on regular dialysis, her blood group O Rh +ve, and received non- specific multiple transfusions
Cross matching were strongly positive (100%) continuously for long period of time. She was referred to the Lab at Bombay Hospital

Summary

Introduction

The reactivity between HLA antigen of donor and ant-HLA antibody of recipient in pre-transplant assessment is one of the critical factors to determining successful transplantation, especially in renal Tx [1].Chronic rejection is a major threat to long term survival of an organ allograft It is presumed that such a rejection is mediated by the Abs development against antigens of allograft and has been observed that the long-term survival of renal allograft is significantly lower in patients who developed anti HLA antibodies following Tx than in patient that do not develop antibodies.An acute rejection occurs more often in pts who have been sensitized to HLA antigens by a previous Tx. Donor selection in pre-sensitized patients for renal transplant SR Kankonkar* Tissue Typing Lab, Bombay Hospital, Mumbai, Maharashtra, India The reactivity between HLA antigen of donor and ant-HLA antibody of recipient in pre-transplant assessment is one of the critical factors to determining successful transplantation, especially in renal Tx [1].

Results

Conclusion