Donor Selection and Outcome for Pediatric Living Donor Kidney Transplant.

Abstract

Preemptive related living donor kidney transplant carries the best outcomes for pediatric patients with end-stage kidney disease. Donor age, sex, and comorbidities are to be considered in selecting donors, including marginal extended criteria donors. Kidney size and number of vessels, to match recipient weight and vasculature, are also important parameters. Genetic screening is occasionally required according to the recipient's primary disease. Posttransplant, follow-up and assessment of living related donors are mandatory to evaluate not only the clinical parameters but also to assess quality of life and social and psychological status. In a 1-year follow-up of 50 donors at Abo El-Reesh Hospital (Cairo, Egypt), there were no significant changes in serum creatinine versus glomerular filtration rate (at normal levels), a 16% elevation of blood pressure, and a tendency of impaired glucose tolerance among female donors. Donors reported positive social and psychological effects. Prompt donor selection before transplant is crucial, and posttransplant care and follow-up are mandatory.