Abstract
Purpose Currently, pulmonary edema in donor lungs is evaluated via surgical inspection and palpation at procurement with no quantitative, standard diagnostic tool in use. The purpose of this study was to investigate the significance of lung weight at the donor hospital (LW0) as an indicator of pulmonary edema and predictor of transplant suitability in ex vivo lung perfusion (EVLP). Methods LW0 was recorded in standard donors (n = 53) and rejected donors (n = 69). Twenty-one rejected lungs were perfused in cellular EVLP and transplant suitability evaluated at 2 hours. Results There was a significant difference in LW0 between standard and rejected donors (814.7 ± 185.9 vs. 956.1 ± 275.1 g, p Conclusion Our findings demonstrate that donor lung weight could be a predictor of P/F ratio and transplant suitability during EVLP. The prospect for recovery of EVLP treated rejected donor lungs improved significantly if they weighed less than 1280 g.
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