Abstract
Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
Highlights
donor islet endothelial cells (DIECs) significantly contributed to the vasculature of fresh islet grafts, assessed up to 5 months after transplantation, but were hardly detected in cultured islet grafts
Grafts originating from cultured islets reversed diabetes more rapidly than those originating from fresh islets
In accordance with our previous data [7], ex vivo confocal and two-photon laser-scanning microscopy imaging 1 month after transplantation showed that DIECs contributed to functional vessels within fresh islet grafts (n = 5; Fig. 1A), whereas only scattered DIECs were found in cultured islet grafts (n = 5; not shown)
Summary
Participation of DIECs in the revascularization process correlated with a higher revascularization rate of freshly isolated islets compared with cultured islets. CONCLUSIONS—In summary, DIECs contributed to the revascularization of fresh, but not cultured, islets by participating in early processes of vessel formation and persisting in the vasculature over long periods of time.
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