Abstract
Objectives We evaluated the impact of spontaneous intracranial bleeding (ICB) in the donor on transplant coronary vasculopathy using serial intravascular ultrasound examinations. Materials and methods Between January 1995 and December 2000, 72 recipients underwent cardiac transplantation from donors who had experienced spontaneous ICB (ICB group). Their findings using serial intravascular ultrasound analysis at baseline (within 1 month) and 1 year after transplantation were compared with 90 recipients who had undergone transplantation from trauma donors (trauma group). Results Compared with the Trauma group, the ICB group showed increased coronary intimal thickness (0.55 ± 0.33 vs 0.39 ± 0.3 mm; P = .034), plaque volume (3.84 ± 2.5 vs 2.28 ± 1.65 mm 3; P = .015) and plaque burden (7.4 vs 2%) at 1 year after transplantation. Conclusions Donor spontaneous ICB is associated with significantly increased coronary vasculopathy.
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