Abstract
Donor-derived acute promyelocytic leukemia presenting as myeloid sarcoma in a transplanted kidney
Highlights
1234567890();,: 1234567890();,: To the Editor: Donor-derived malignancies after solid organ transplantation have an estimated incidence of 0.02–0.2%, and donor-derived leukemia is uncommon [1,2,3]
We present the case of a patient diagnosed with acute promyelocytic leukemia (APL) presenting as myeloid sarcoma in a transplanted kidney allograft
Flow cytometry of cells derived from the urine demonstrated the same abnormal myeloid blast population (17% of leukocytes)
Summary
1234567890();,: 1234567890();,: To the Editor: Donor-derived malignancies after solid organ transplantation have an estimated incidence of 0.02–0.2%, and donor-derived leukemia is uncommon [1,2,3]. We present the case of a patient diagnosed with acute promyelocytic leukemia (APL) presenting as myeloid sarcoma in a transplanted kidney allograft. The neoplastic cells were demonstrated to be donor-derived in origin; other organ recipients from the same donor were subsequently tested and had PML-RARα transcripts detected in their peripheral blood.
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