Abstract
Donor cell leukemia (DCL) represents a rare complication of allogeneic transplantation. The precise incidence remains unclear, though it may be higher following umbilical cord blood transplants. Here, we present an unusual case of a patient with B-ALL who presented with a donor derived myeloid sarcoma of the heart following a double cord blood transplant. To our knowledge, it is the first case of sarcomatous or chloromatous presentation of DCL following a UCBT.
Highlights
Donor cell leukemia (DCL) represents a rare complication of allogeneic transplantation
We present an unusual case of a patient with prior history of B acute lymphoblastic leukemia (B-ALL) who presented with a donor derived myeloid sarcoma of the pericardium following a double cord blood transplant
A bone marrow biopsy was performed, which revealed a donor derived acute myeloid leukemia (AML), with 22% blasts showing an immature myeloid phenotype by flow cytometry (CD13+, CD34+, HLA-DR+, CD4dim+, CD64dim+, and CD33 partial dim+), negative for CD10 and CD19, both of which had been expressed in the prior B-ALL
Summary
Donor Cell Myeloid Sarcoma in an Umbilical Cord Transplant Patient: A Case Report and a Review of the Literature. Donor cell leukemia (DCL) represents a rare complication of allogeneic transplantation. The precise incidence remains unclear, though it may be higher following umbilical cord blood transplants. We present an unusual case of a patient with B-ALL who presented with a donor derived myeloid sarcoma of the heart following a double cord blood transplant. To our knowledge, it is the first case of sarcomatous or chloromatous presentation of DCL following a UCBT
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