Abstract
A 4‐methylene‐5‐spirocyclopropane isoxazolidine was prepared with complete regioselectivity through the 1,3‐dipolar cycloaddition reaction of a pyrroline N‐oxide with a cyclopropylidene acetate, followed by reduction and elimination. Thermal rearrangement of the isoxazolidine gives an indolizidinone that retains the exocyclic methylene moiety. The exo‐methylene substituent confers a particular reactivity to this heterocycle; it can undergo thermal hetero‐Diels–Alder cycloadditions and ene reactions with different reaction partners.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
