Abstract
AbstractDomino Liver transplant (DLT) is a surgical strategy to expand the liver donor pool, addressing the organ shortage, in selected patients who would otherwise not have the opportunity to benefit from liver transplantation. In this sense, DLT uses morphologically normal livers from donors with certain metabolic disorders (familial amyloidotic polyneuropathy, primary hyperoxaluria, acute intermittent porphyria, maple syrup urine disease, and homozygous familial hypercholesterolemia) in selected recipients, usually with hepatocellular carcinoma (generally outside the Milan criteria). However, the benefit of expanding the donor pool must be balanced against the risk of metabolic disease transmission. Despite some typical technical challenges, DLT appears to be a safe and reasonable transplant option.KeywordsLiver transplantationDomino liver transplantationDonor poolMetabolic disordersHepatocellular carcinoma
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