Abstract
Domino intramolecular Diels-Alder (IMDA) reactions towards the 6/6/5/5 fused tetracyclic natural products were developed in satisfactory yield and high stereoselectivity. Four rings, six contiguous stereocenters and four C-C bonds were formed in a single operation. 4-epi-Hydromitchellene B was also synthesised efficiently via this strategy.
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