Domino [3+2+1] heterocyclization of isothiocyanates with aryl amidines leading to polysubstituted 1,3,5-triazine derivatives

Abstract

Concise and efficient domino [3+2+1] heterocyclization of isothiocyanates with aryl amidines has been established for the synthesis of 1,3,5-triazine derivatives. The multicomponent domino reaction (MDR, AB2 type) is easy to perform simply by mixing inexpensive isothiocyanates and aryl amidines in the presence of NaOH under microwave heating. The present synthesis shows attractive properties such as concise one-pot conditions, short reaction periods (15–24min), and easy purifications. The resulting 1,3,5-triazine derivatives are important structural motifs in organic and medicinal research.