Abstract
Summary Male mice of the inbred strain DBA/2J were given by gavage 150 mg/kg body weight of ethyl methanesulfonate (EMS). The rate of induction of dominant lethal mutations was estimated from uterine scars of parental females after progeny had been weaned. Since 85% of all conceptions took place during the first 7 days postinjection, the estimated rate of occurrence of dominant lethal mutations is based primarily on those mutations which have occurred in spermatozoa in the vas and epididymis. The frequency of dominant lethals in the treated groups was significantly greater than that of the control groups.
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