Domestic gather of analysis on clinical data of pulmonary aspergillosis in recent 20 years

Abstract

Objective To know the epidemiology, clinical and imageology characteristic, diagnosis, misdiagnosis,treatment and prognosis of pulmonary aspergillosis reported in China,in an attempt to provide important clues for prompt and accurate diagnosis. Methods Retrospective analysis includes 27 pieces of reporters from 1988 to 2007 in China and the clinical data of 293 patients with pulmonary aspergillosis are summarized. Results There are 181 cases (61.8%) with pulmonary aspergillosis hall, 107 cases (36.5%) with invasive pulmonary aspergillosis and 5 cases (1.7%) with allergic bronchopulmonary aspergillosis in 293 cases of patients. Pulmonary aspergillosis occurred in the patients who have chronic pulmonary diseases or other chronic diseases. The males are more than the females in a ratio of 2 : 1. The clinical manifestations of pulmonary aspergillosis have no specificity and the imageology manifestation is in variety, so its clinical misdiagnosis rate reaches up to 74.6%. Its final diagnosis mainly depends on smear,cultivation of respiratory tract secretion and pathologic test of the lung. Therapeutic tool involved resection with operation and the application of anti-fungi drugs. Conclusions The diversity of clinical manifestations in pulmonary aspergillosis have resulted in higher clinical misdiagnosis rate. It is hoped that this article can provide some valuable clues for the clinicians. Key words: Lung; Aspergillosis; Invasive; Infection; Therapy