Abstract
The surface chemistry of nanoparticles dominantly determines their interactions with biomembranes and potential cytotoxicity. However, little is known about the biological impacts of nanomaterials with anisotropic surface chemistry. In this presentation, I will demonstrate our work on understanding interactions of anisotropic nanoparticles with lipid membranes, using nanoparticles that display spatially separated hydrophobic and charged ligands on opposite sides. These amphiphilic nanoparticles, called Janus nanoparticles, disrupt and deform lipid vesicle membranes, including membrane wrinkling, protrusion, poration, and even collapse of entire vesicles.
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