Dolor irruptivo refractario a ketamina y metadona resuelto con abordaje multimodal

Abstract

We report the case of a 28 year-old patient with a giant cell sacral bone tumour with pelvic invasion for two years, who maintained an excellent functional status. During this time she was cared for by the Home Care Support Team, with two admissions to a chronic Palliative Care Unit. The patient was admitted to our acute Palliative Care Unit for the management of severe breakthrough pain in the right lower limb with 10/10 intensity, associated to severe toxicity induced by ketamine. The multiple pain crises were not adequately controlled with a combination of methadone, venlafaxine, gabapentin, acetaminophen, antiinflammatory drugs, steroids, diazepam, baclofen and ketamine. After an adequate clinical – radiological identification of the origins of the pain crises, the pain was successfully controlled with a multimodal therapeutic approach. This approach included discontinuation of ketamine, opioid rotation to morphine, titration of baclofen doses, palliative radiotherapy and biphosphonates.