Abstract
Dolichyl phosphate (Dol-P) is a long chain polyisoprenoid which transfers saccharide residues in N-linked glycoprotein synthesis. It is synthesized by a quantitatively small branch of the cholesterol pathway at a rate which, at least in liver, appears to be independent of the rate of sterol synthesis. This article reviews recent work on the fate of dolichol compounds and the regulation of Dol-P synthesis.
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