Abstract
Dolabellane diterpenoids, (1 R,3 E,7 E,10 S,11 S,12 R)-dolabella-3,7-dien-10,18-diol ( 1), (1 R,3 S,7 E,11 S,12 R)-dolabella-4(16),7-dien-3,18-diol ( 2), (1 R,7 E,11 S,12 R)-18-hydroxydolabella-4(16),7-dien-3-one ( 3), (1 R,3 S,4 S,7 E,11 S,12 R)-3,4-epoxydolabella-7-en-18-ol ( 4), and (1 R,3 R,7 E,11 S,12 R)-dolabella-4(16),7,18-trien-3-ol ( 5), were obtained from the ornamental plant Aglaia odorata. Their structures were characterized on the basis of spectroscopic analyses and further confirmed by X-ray diffraction. Compounds 1 and 5 showed weak cytotoxicity against the human myeloid leukemia HL-60, hepatocellular carcinoma SMMC-7721, and lung cancer A-549 cells.
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