Abstract
Objective: It is not known whether inhibition of ?1-adrenoreceptor in a rat model of partial bladder outlet obstruction (BOO) causes decrease in tubular and glomerular cell death by apoptosis and prevention of subsequent inflammation and fibrosis. The aim of this study was to demonstrate the relationship between apoptosis and doxazosin ?1-adrenoceptor antagonist) in rat kidneys damaged by partial BOO. Material and Methods: A total of 45 adult female Wistar rats,with a mean weight of 250 g were randomly allocated to four experimental groups as: sham-operated rats (10 rats), sham-operated rats treated with doxazosin (10 rats), partial BOO group (14 rats), and partial BOO group treated with doxazosin (11 rats). Partial BOO was surgically induced. Detection of cell apoptosis was done by TUNEL assay. Results: This investigation revealed increased apoptosis in both tubular and glomerular cells of rats with partial BOO. Furthermore, the results of this study demonstrated that doxazosin treatment of rats reduced apoptosis in tubular and glomerular cells in both the controls and the rats with partial BOO. Conclusion: We believe that our observation of decreased apoptosis in both tubular and glomerular cells of rats with partial BOO might be useful to gain new insight into the therapeutic effect of doxazosin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
