Abstract

We wish to respond to the article “Going native, or the risk of overreliance on recombinant antigens” ([1][1]) by Dr. Lopez-Perez, which questions our findings that antibodies to VAR2CSA can arise outside pregnancy. She asserts that relying on antibody recognition of recombinant proteins can

Highlights

  • Lopez-Perez, which questions our findings that antibodies to VAR2CSA can arise outside pregnancy

  • She asserts that relying on antibody recognition of recombinant proteins can yield misleading data on VAR2CSA antibody responses

  • We contend that the most important way to characterize VAR2CSA antibodies is not based exclusively on antigen recognition but on whether those antibodies block the adhesion of infected erythrocytes (IE) to the placental receptor chondroitin sulfate A (CSA)

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Summary

Introduction

We wish to respond to the article “Going native, or the risk of overreliance on recombinant antigens” [1] by Dr Lopez-Perez, which questions our findings that antibodies to VAR2CSA can arise outside pregnancy.

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