Abstract
The objective of this study was to investigate the effect of whole body vibration (WBV) exercise on oxidative stress markers in a group of women with fibromyalgia (FM) compared to a group of healthy women (CT). Twenty-one women diagnosed with FM and 21 age- and weight-matched healthy women were enrolled the study. Plasma oxidative stress markers (primary outcomes) were evaluated at rest and after WBV, and included thiobarbituric acid reactive substances (TBARS), iron reduction capacity (FRAP), superoxide dismutase antioxidant enzymes activity (SOD), and catalase (CAT). At rest, the FM group had higher TBARS (P<0.001) and FRAP (P<0.001), and lower CAT (P=0.005) compared to the CT. In the CT group, the WBV had no effect on TBARS (P=0.559) and FRAP (P=0.926), whereas it increased both SOD (P<0.001) and CAT (P<0.001). In the FM group, the WBV reduced TBARS (p <0.001), FRAP (P<0.001), and CAT (P=0.005), while it increased SOD (P=0.019). There was an interaction effect (moments vs groups) in the TBARS (effect size=1.34), FRAP (effect size=0.93), CAT (effect size=1.45), and SOD (effect size=1.44) (P<0.001). A single trial of WBV exercise improved all oxidant and antioxidant parameters towards a greater adaptation to the stress response in FM women.
Highlights
Fibromyalgia (FM) syndrome is a chronic disorder characterized by generalized and persistent musculoskeletal pain that predominantly affects women
The sample size was calculated from a pilot study consisting of 8 subjects diagnosed with fibromyalgia and 8 healthy matched subjects, in which we evaluated the effect of whole body vibration (WBV) exercise on plasma thiobarbituric acid reactive substances (TBARS) level before and after a single WBV exercise intervention
To the best of our knowledge, this is the first study investigating the effects of a single trial of WBV exercise on oxidative stress markers in FM women compared to a healthy matched group
Summary
Fibromyalgia (FM) syndrome is a chronic disorder characterized by generalized and persistent musculoskeletal pain that predominantly affects women (between 61 and 90% of affected persons). RNS are highly reactive chemical species with an unmatched electron formed by catalyzing transition metals like iron, copper, or manganese. These toxic molecules become highly reactive in their formation because of their altered number of unmatched valence electrons. These RNS are suggested to play important roles in rheumatologic conditions like rheumatoid arthritis, ankylosing spondylitis, and chronic fatigue syndrome (CFS) [4,5]. Studies report an association between oxidative stress and insulin resistance suggesting that increased levels of ROS are an important triggering factor for insulin resistance in various contexts [8]. Fava et al [9] reported that substrate changes of the insulin receptor are sensitive to changes in cognitive status in FM
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