Abstract
To the Editor: Vitamin D deficiency is a significant riskfactor for type 2 diabetes, although the effect of vitamin Dsupplementation for treatment of type 2 diabetes is stillunder debate [1–3]. It has also been reported that vitamin Dreceptor (VDR) is present in caveolae [4]. Dr Boucher hastherefore posed two important questions [5] in response toour study [6] on caveolin-1 in an ageing-dependent non-obese type 2 diabetic animal model (JYD mouse): (1)whether insulin sensitivity could be improved by vitamin Din JYD mice; and (2) whether such an improvement mightbe due to an upregulation of caveolin-1 production affectedby vitamin D.To answer Dr Boucher's first question, we measuredglucose tolerance and insulin sensitivity in 30-week-oldJYD mice treated with 1,25-dihydroxycholecalciferol[1,25(OH)
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