Does trigeminal nociception influence the visual cortex: a study of the effects of supraorbital electro- or chemo-nociceptive stimulation

Abstract

Event Abstract Back to Event Does trigeminal nociception influence the visual cortex: a study of the effects of supraorbital electro- or chemo-nociceptive stimulation Simona Liliana Sava1*, Victor De Pasqua1, Delphine Magis1 and Jean Schoenen1 1 Headache Research Unit, Liège, University Department of Neurology, Belgium Background and aims : In migraine pathophysiology, the link between the visual cortex and the trigeminovascular system might play a pivotal role. In a previous study we showed the top-down relation between the visual cortex and the trigeminal nociceptive system. To search for the existence of a bottom-up relationship we studied the effect of electrical stimulation or application of capsaicin in the territory of the 1st division of the trigeminal nerve on pattern-reversal visual evoked potentials (PR-VEP). Methods: We recorded 600 responses of PR-VEP at 3.1 Hz before and after the trigeminal stimulation. The electrical stimuli were delivered over the supraorbital nerve for 20 min at 16 mA and 100 Hz in 7 healthy volunteers (HV). Capsaicin (cream 3%) was applied over the right frontal area for 1h in 8 HV. We measured PR-VEP N1, P1 and N2 latencies, N1-P1 and P1-N2 amplitudes in six sequential blocks of 100 sweeps and habituation as the change in amplitude over the six blocks. Results: The electrical stimulation increased the latency of P1 (p=0.027) and N2 (p=0.042) but left habituation unchanged. The capsaicin application increased habituation between the 1st and 2nd block of 100 responses (p=0.049) but had no significant effect on latencies. Conclusions: These results suggests that a bottom-up relation exists between the trigeminal (V1) afferent nociceptive pathway and the visual cortex. Interestingly, an increase in PR-VEP habituation, such as found after capsaicin, also occurs during the migraine attack, where it replaces the interictal deficit of habituation. References Sava SL, Schoenen J (2011) Repetitive transcranial magnetic stimulation modulates the nociceptive-specific blink reflex in healthy subjects but not in migraineurs. Cephalalgia, IHS-Berlin Sava SL, Schoenen J (2010) Repetitive transcranial magnetic stimulation over the visual cortex modulates trigeminal nociceptive pathways. EHMTIC-Nice Drummond PD (1986) A quantitative assessment of photophobia in migraine and tension headache. Headache 26:465–469. Lambert GA, Hoskin K, Zagami AS (2008) Cortico-NRM influences on trigeminal neuronal sensation. Cephalalgia 640–652. Boulloche N, Denuelle M (2010). Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain. J Neurol Neurosurg Psychiatry. 81(9):978-84. Reyes-Escogido Mde L, Gonzalez-Mondragon EG (2011) Chemical and pharmacological aspects of capsaicin. Molecules. 28;16(2):1253-70. de Tommaso M, Losito L, (2005) Capsaicin failed in suppressing cortical processing of CO2 laser pain in migraine patients. Neurosci Lett.12-19;384(1-2):150-5. de Tommaso M, Sardaro M (2007) Effects of the remote C fibres stimulation induced by capsaicin on the blink reflex in chronic migraine. Cephalalgia 27(8):881-90. Keywords: Migraine, Headache Disorders, Trigeminal Nerve, Capsaicin, Electric Stimulation, Pain Conference: Belgian Brain Council, Liège, Belgium, 27 Oct - 27 Oct, 2012. Presentation Type: Poster Presentation Topic: Other basic/clinical neurosciences topic Citation: Sava S, De Pasqua V, Magis D and Schoenen J (2012). Does trigeminal nociception influence the visual cortex: a study of the effects of supraorbital electro- or chemo-nociceptive stimulation. Conference Abstract: Belgian Brain Council. doi: 10.3389/conf.fnhum.2012.210.00105 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Aug 2012; Published Online: 12 Sep 2012. * Correspondence: Mrs. Simona Liliana Sava, Headache Research Unit, Liège, University Department of Neurology, Liège, 4000, Belgium, simonaliliana.sava@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Simona Liliana Sava Victor De Pasqua Delphine Magis Jean Schoenen Google Simona Liliana Sava Victor De Pasqua Delphine Magis Jean Schoenen Google Scholar Simona Liliana Sava Victor De Pasqua Delphine Magis Jean Schoenen PubMed Simona Liliana Sava Victor De Pasqua Delphine Magis Jean Schoenen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.