Abstract
Abstract Background Hyperglycemia at the time of admission is related to increased mortality and poor prognosis in patients diagnosed with ST-segment elevation myocardial infarction (STEMI). Objective We aimed to investigate whether tight glucose control during the first 24 hours of STEMI decreases the scintigraphic infarct size. Methods The study population consisted of 56 out of 134 consecutive patients hospitalized with STEMI in a coronary care unit. Twenty-eight patients were treated with continuous insulin infusion during the first 24 hours of [...]
Highlights
Hyperglycemia has become a predictor of mortality and morbidity in patients with acute coronary syndrome (ACS).[1]
We aimed to investigate the effects of tight glucose control with continuous insulin infusion during the first 24 hours of hospitalization on final infarct size in segment elevation myocardial infarction (STEMI) patients
Our results demonstrated that reduced blood glucose levels during the first 24 hours of STEMI was related to smaller infarct size
Summary
Hyperglycemia has become a predictor of mortality and morbidity in patients with acute coronary syndrome (ACS).[1] High blood glucose levels cause increased mortality, larger infarct size, unsuccessful reperfusion, and prolonged hospitalization.[2,3] Glucose has direct harmful effects on the myocardial tissue by increasing the levels of oxygen radicals, free fatty acids, ketones, and lactate. It enhances platelet aggregation and activates other mediators in the coagulation system, leading to unsuccessful reperfusion.[4]. Conclusion: Tight glucose control with continuous insulin infusion was not associated with smaller infarct size when compared to standard care in STEMI patients. (Int J Cardiovasc Sci. 2020; 33(5):497-505) Keywords: ST-Elevation Myocardial Infarction/mortality/mortality; Hyperglycemia; Hospitalization; Insulin; Tomography, Emission Computed,Single Photon/methods; Myocardial Perfusion Imaging
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