Abstract

Vol 350 • July 5, 1997 31 about folic acid. However, 38·8% of women interviewed started to take supplements only after conception, and most after the fifth week of pregnancy, which may well offer little or no protection since neural-tube closure is 26–27 days after conception. 35·9% of pregnancies in this study were unplanned. Thus, potentially 64·1% of women could have taken preconceptional folate. Although there has been increased awareness of folic acid for prevention of neuraltube defects, there is still a long way to go.

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