Abstract
The aim of this experimental study is to evaluate oxidant/antioxidant status and the end products of lipid peroxidation in the liver of rats exposed to subacut formaldehyde (FA) inhalation (4-weeks). Thirty male Wistar albino rats divided into 3 separate groups randomly (10 for each group). Rats were exposed to atmospheres containing 0, 10 and 20 ppm FA continuously (8 hours per day, 5 days per week). Reduced glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels, as well as xanthine oxidase (XO), and myeloperoxidase (MPO) activities were measured in rat liver homegenates. The results showed a remarkable reduction of GSH content (10 and 20 ppm FA) and XO activity (20 ppm FA) in liver tissues from rats exposed to for 4weeks (p<0.005, p<0.0001 and p<0.0001, respectively). MDA and NO levels did not change in both two groups (10 ppm and 20 ppm). These findings suggest that the antioxidant system of liver tissue is moderately impaired by excessive FA exposure. The GSH has an important influence especially on subacute FA liver toxicity. GSH-related cellular defensive mechanisms may be deppressed and susceptibility to oxidative damage may high in rats exposed to FA subacutely.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
