Abstract
The low serum level of testosterone in the elderly subjects may be a contributing factor for coronary artery disease (CAD) through many pathways.The aim of this work is to study serum levels of free testosterone in elderly men with CAD (both those with acute coronary syndrome (ACS) and those with stable CAD). This study was conducted on 100 elderly males with CAD ,one half of them (50 patients) was presented with ACS (with mean age 69.6± 2.44 year), and the other half (50 patients) was presented with stable CAD (with mean age 69.42± 2.14year), in addition to 50 apparently healthy elderly males (with mean age 69.06 ± 1.64year) as a control group. We detected the levels of serum free testosterone, cortisol, fibrinogen, plasminogen activator inhibitor-1(PAI-1), high sensitive C-reactive protein(hsCRP), interleukin-6(IL-6). Cases with CAD had significant lower values of free testosterone and HDL-c, but they had significant higher values of cortisol, fibrinogen, PAI-1, IL-6, hsCRP, in comparison to control group. Cases with ACS had significant higher values of cortisol, hsCRP, IL-6, fibrinogen, PAI-1, total cholesterol and BMI more than those with stable CAD. The free testosterone had significant negative correlation with fibrinogen, PAI-1, , hsCRP and IL-6 in both groups of patients. The lower value of serum free testosterone in elderly male subjects may contribute to CAD in them via multiple mechanisms including increase blood pressure, dyslipidemia, obesity, increased blood coagulation and increased inflammatory activity.
Highlights
Coronary artery disease (CAD) is common in old people and accounts for about half of all deaths in those people [1]
The aim of this work is to study the levels of serum free testosterone in elderly patients with coronary artery disease (CAD), and the correlation of free testosterone with levels of serum cortisol, fibrinogen, plazminojenetkinleştirici inhibitör- 1 (PAI-1), high sensitive C-reactive protein (hsCRP), and IL-6 in those patients
Cases with acute coronary syndrome have significant higher values of BMI, total cholesterol, cortisol, hsCRP, IL-6, fibrinogen and PAI-1 more than those with stable CAD, while there is no significant difference as regard free testosterone between both groups as shown in table [2]
Summary
Coronary artery disease (CAD) is common in old people and accounts for about half of all deaths in those people [1]. Phillips et al (1994) [2] reported that low total and free testosterone levels were inversely linked to coronary artery disease, even after adjusting for age and adiposity. This idea was supported by another study , in which men with angiographically proven CAD has lower levels of testosterone than those of control subjects, and the testosterone levels were negatively correlated to the degree of coronary involvement [3]. The aim of this work is to study the levels of serum free testosterone in elderly patients with CAD (both those presenting with acute coronary syndrome and others with stable CAD), and the correlation of free testosterone with levels of serum cortisol, fibrinogen, PAI-1, hsCRP, and IL-6 in those patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
