Does The Scientific Evidence Support the Idea of Promoting Sucralfate as The First Aid Topical Management for Burn Wound? A Literature Review

Abstract

Burn injuries, caused by heat, chemicals, radiation, or electricity, significantly impact morbidity and mortality. Sucralfate, a mucoprotective agent composed of sucrose sulfate and aluminum hydroxide, forms a protective barrier on wounds, reduces pain, stimulates healing, and has anti-inflammatory effects. By stimulating prostaglandin secretion and binding to proteins in the ulcer bed, sucralfate enhances gastrointestinal mucosa defenses and acts locally in injured tissues, minimizing systemic effects. Clinical studies demonstrate its effectiveness in improving wound healing, reducing pain, and promoting tissue regeneration, angiogenesis, and granulation tissue development in burn patients. For optimal burn wound therapy, proper patient selection, formulation techniques, and integration with standard protocols are crucial. Further large-scale randomized controlled trials are necessary to establish guidelines and expand sucralfate's clinical applications.