Does the deficiency of 25-hydroxy vitamin D effect the placental peptides (free β-human chorionic gonadotropin and pregnancy-associated plasma protein A ) levels ?

Abstract

SummaryObjectiveIn this study, we analysed that low maternal 25 hydroxy vitamin D (25(OH)D) levels cause an increase in the level of 1,25 dihydroxy vitamin D in the syncytiotrophoblasts by placental hydroxilation and also we analysed the effects of low syncystiotrofoblastic stimulation on placental peptides (free β-human chorionic gonadotropin and pregnancy-associated plasma protein A) secretion..Material and MethodsThis retrospective study was included 225 pregnant women at 11-14 weeks of gestation attending the outpatient clinic of our hospital for first trimester screening test from January 2017 to December 2017. Vitamin D levels were deficient in 145 pregnant women and adequate in 80 pregnant women. Serum 25(OH)D concentrations were measured at 11–14 weeks gestation in 225 singleton pregnancies using liquid chromatography-tandem mass spectrometry in the same labaratory. We assessed the relationship between vitamin D, free β-human chorionic gonadotropin ( free β-hCG) and pregnancy associated plasma protein A (PAPP-A) levels during pregnancy.Results: There was a negative correlation between PAPP-A levels and maternal age at sampling (p=0.219). There was a positive correlation between free β-hCG levels and maternal age at sampling (p=0.034). There was a negative correlation between Low 25(OH)D levels and free β-hCG levels (p=0.071). There was a positive correlation between Low 25(OH)D levels and PAPP-A levels (p=0.414).Conclusion There was no statistically significant relationship between free β-hCG, PAPP-A levels and vitamin D in the first trimester.