Does the breakdown of the detoxification system for aldehydes as a result of aldose reductase upregulation lead to alcohol-induced liver injury in humans and mice?

Abstract

Alcohol-induced liver disease (ALD) is one of the major causes of chronic liver disease globally. The pathogenesis of alcohol-induced hepatic injury is characterized by steatosis, inflammation and fibrosis, which can eventually progress to cirrhosis and hepatocellular carcinoma1) . Recently, the mechanism of both ALD and non-alcoholic fatty liver disease (NAFLD) has been fairly well studied, but a successful treatment for ALD and NAFLD is not available yet.