Does serum Vitamin D affect lipid profile?

Monalisa Biswas,Krishnananda Prabhu,Allabhakshu Shaik

doi:10.51248/.v41i4.908

Monalisa Biswas, Krishnananda Prabhu + Show 1 more

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https://doi.org/10.51248/.v41i4.908

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Abstract

Introduction and Aim: Vitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus. Despite speculations regarding implications of its deficiency on the cardio metabolic health of general/ susceptible population, its role remains underexplored in the Indian population. Materials and Methods: This cross-sectional study carried out in Biochemistry Department of the institution, recruited 219 patients (after obtaining written consent) of both genders above18 years who underwent Vitamin D testing. Blood samples obtained were assayed for HbA1c, C Reactive protein, thiol and lipid. Kruskal Wallis test and Spearman correlation were employed for statistical analysis. Results: Significantly low HDL and high atherogenic index of plasma (AIP) were observed in males with vitamin D deficiency. Significant inverse correlation of vitamin D with CRP and total cholesterol (among vitamin D deficient males) was observed. A significant inverse correlation between serum HDL and AIP and a significant direct correlation between triglyceride and AIP were observed irrespective of their vitamin D status. Heat map showed marginally elevated lipid parameters among vitamin D insufficient males. Conclusion: Vitamin D may emerge as a surrogate marker in risk stratification of patients with diabetes and dyslipidaemia. More insights are required to assess the gender specific susceptibility to dyslipidaemia and atherosclerosis in relation to vitamin D levels.

Highlights

Introduction and AimVitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors
Evidence suggests vitamin D deficiency might lead to beta cell dysfunction and progressive insulin resistance, increasing the susceptibility to the develop metabolic syndrome along with increase in glycated haemoglobin [1]
These series of effects triggered by hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus [1]

Summary

Introduction

Introduction and AimVitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Despite being located near the equatorial region; India is endemic to vitamin D deficiency with an estimated 50% of the population (or more) manifesting a varying spectrum of vitamin D insufficiency [2]. Evidence suggests vitamin D deficiency might lead to beta cell dysfunction and progressive insulin resistance, increasing the susceptibility to the develop metabolic syndrome along with increase in glycated haemoglobin [1]. These series of effects triggered by hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus [1]. India reports a high prevalence of vitamin D deficiency among all ages, genders, varying socioeconomic groups, urban and rural populations, pregnant and post-menopausal women, and healthy young adults [5,6,7]

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