Abstract
Does Restricted Use of Repeat Doses of Surfactant after the Prophylactic Dose Increase the Risk of BPD or Death in Preterm Infants?
Highlights
Surfactant replacement therapy in the treatment of neonatal respiratory distress syndrome secondary to immaturity-related surfactant deficiency has been established as an effective and safe therapy since the early 1990s [1]
Restricting repeat doses of Survanta did not increase the risk of development of BPD or death in preterm infants with respiratory distress syndrome (RDS)
This contrasts with a rescue or treatment surfactant strategy, in which surfactant is given to preterm infants with a diagnosis of RDS based on signs and symptoms and chest radiographic findings consistent with RDS
Summary
Surfactant replacement therapy in the treatment of neonatal respiratory distress syndrome secondary to immaturity-related surfactant deficiency has been established as an effective and safe therapy since the early 1990s [1]. Administration of beractant every 12 hours vs every 6 hours as recommended by the manufacturer found no difference in duration of mechanical ventilation and length of hospital stay [16] Based on this introduction it is evident that there is still significant debate regarding the need for the initial and subsequent surfactant treatment and the frequency of administration for improvement of associated morbidity and mortality due to neonatal RDS. We introduced a practice change in early 2008 whereby prophylactic surfactant administration was limited to infants
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