Does resting state functional connectivity differ between mild cognitive impairment and early Alzheimer's dementia?

Abstract

PurposeThis study aimed to investigate differences in functional connectivity (FC) among different resting state networks (RSN) in clinically non-progressive mild cognitive impairment (MCI) and Alzheimer's disease (AD). MethodsUsing 3T MRI acquired resting-state functional MRI (rs-fMRI), we attempted identification of different RSN using independent component analysis (ICA) in amnestic-MCI, convertors to early AD and age-matched cognitively normal healthy controls. Regions of interest (ROI) that showed significant differences in connectivity on group ICA were selected as seeds for seed-voxel analysis. Group differences in FC for each network-connectivity map were entered into a general linear model with age, gender and total intra-cranial volume (TIV) as covariates. ResultsIn this cross-sectional design 31 HC, 30 MCI and 30 MCI-convertors to early AD were evaluated. Seed-based analysis between AD and controls revealed reduced posterior connectivity within the default mode (DMN), dorsal attention (DAN) and antero-posterior connectivity with sensori-motor (SMN) networks. Reduced cerebellar connectivity of DMN and posterior connectivity within the frontal parietal network (FPN) separated AD from MCI. MCI-control comparisons revealed differences only on ICA. Positive correlation was observed between FC in DMN network clusters with verbal list-learning (r = 0.50) and recall scores (r = 0.51) in AD, the latter additionally demonstrating correlation with SMN clusters (r = 0.50). ConclusionsWidespread network hypo-connectivity is apparent in AD as opposed to MCI non-convertors in comparison to controls, along with positive correlation with memory scores. Reduced connectivity involving DMN and FPN helps to differentiate between AD and MCI-nonconvertors to dementia. Longitudinal studies are required into utility of these measures.