Abstract
The objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms. Postmenopausal women enrolled in a randomised controlled trial were allocated to either a sedentary control group (n = 29) or a RT group (n = 26). Blood samples were taken at week-0 and week-15 for all participants. Blood lipids and iron status were measured via routine clinical analyses. Immunoassays were used to measure oxidative stress markers. The RT group, with good compliance, was associated with significant reductions in ferritin, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol. Moreover, ferritin was positively correlated with atherogenic lipids while negatively correlated with high-density lipoprotein in RT women. This occurred without alterations in serum iron, transferrin, transferrin-saturation, C-reactive protein and oxidative stress markers. No differences were found in control women. This study suggests that RT in postmenopausal women both reduces levels of ferritin and counteracts atherogenic lipid profiles independent of an apparent oxidative mechanism. RT may be a beneficial intervention in postmenopausal women via an interaction between ferritin and lipids; however, further investigation in a larger cohort is essential.
Highlights
The objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms
Significant decreases were observed in the compliant-RT group in total cholesterol, low-density lipoprotein (LDL), and non-high-density lipoprotein (HDL) cholesterol (Table 2)
For the first time, we demonstrate that ferritin in postmenopausal women participating in RT over 15 weeks was positively correlated with atherogenic lipids including triglycerides, non-HDL and apolipoprotein-B, while negatively correlated with HDL
Summary
The objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms. Ferritin was positively correlated with atherogenic lipids while negatively correlated with high-density lipoprotein in RT women This occurred without alterations in serum iron, transferrin, transferrin-saturation, C-reactive protein and oxidative stress markers. Moderate aerobic exercise and RT have both shown beneficial effect in lowering inflammatory activity[12] It is unknown whether RT causes a correlative change in lipid profile, body iron status, and oxidative stress in postmenopausal women. The aim of this study was to determine if a RT based 15 weeks regime of physical exercise can alter the blood lipid profile, body iron burden and oxidative stress in a cohort of postmenopausal women. The hypothesis for this study is that 15 weeks of RT in postmenopausal women will improve the blood lipid profile by reducing LDL and increasing HDL, and to reduce body iron burden and oxidative stress levels
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