Does Recombinant Human Bone Morphogenetic Protein-2 (BMP) Use in Adult Spinal Deformity (ASD) Increase Complications and Are Complications Dose Related? A Prospective Multicenter Study of 257 Consecutive Patients

R Shay Bess,Eric O Klineberg,Vedat Deviren,Justin S Smith,Douglas C Burton,Christopher P Ames,Khaled M Kebaish,Michael O’Brien,Richard Hostin,Gregory M Mundis,Robert A Hart,Behrooz A Akbarnia,Christopher I Shaffrey,Munish C Gupta,Oheneba Boachie-Adjei,Kirkham B Wood,Breton Line,Virginie Lafage,Frank J Schwab

doi:10.1016/j.spinee.2012.08.036

Abstract

Off label BMP use in ASD surgery has increased, however BMP associated complications and under-reporting of acute complications have come under scrutiny. Little multicenter, prospective data exists on BMP use for ASD. Purpose: evaluate BMP associated complication rates following ASD surgery.

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