Abstract
Aims: The aim of this study was to investigate the potential protective effect of Ramelteon (RMT), which exhibits antioxidant, anti-inflammatory and antiapoptotic properties, against testicular damage induced by Methotrexate (MTX), which is widely used in the treatment of various diseases, including chemotherapy.
 Methods: 32 Wistar albino rats were equally divided into four groups: Control (group I), MTX (group II), MTX+RMT (group III) and RMT (group IV). Histologic evaluation was performed using Hematoxylin and Eosin (H&E) staining, immunohistochemical analysis using TNF-alpha and Cas-3, and biochemical evaluation using TAS, TOS and OSI.
 Results: Histologic analysis using H&E staining revealed a significant difference between group I and groups II and III (p0.05). While normal histologic structures were observed in groups I and IV, histopathologic findings were noted in groups II and III. Immunohistochemical evaluation of TNF-alpha and Cas-3 showed a significant difference between group I and groups II and III (p0.05). The highest immunostaining intensity was observed in group II. Biochemical evaluation revealed statistically significant differences in TAS, TOS and OSI parameters reflecting oxidative stress differences between the groups (p
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