Abstract
Methods Time-kill curves of daptomycin, doripenem, linezolid, moxifloxacin, and tigecycline were determined for Staphylococcus aureus ATCC 29213 and of colistin, doripenem and moxifloxacin for a clinical isolate of Pseudomonas aeruginosa at concentrations above or equal to the respective MICs. All experiments were performed over 24 h in Mueller-Hinton broth (MHB) and in MHB enriched with porcine surfactant at a concentration of 1 mg/mL (MHBsurf).
Highlights
Activity of antimicrobial agents may be affected by pulmonary surfactant
This study set out to assess the impact of pulmonary surfactant in vitro on bacterial killing of other antibiotics used for treatment of pneumonia
The activity of moxifloxacin against S. aureus was reduced in vitro by addition of surfactant whereas this effect could not be observed against P. aeruginosa
Summary
Activity of antimicrobial agents may be affected by pulmonary surfactant. It was reported that the clinical efficacy of daptomycin is significantly impaired in pneumonia in spite of bacterial susceptibility in vitro. This study set out to assess the impact of pulmonary surfactant in vitro on bacterial killing of other antibiotics used for treatment of pneumonia
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