Abstract
Introduction: Osteoarthritis is one of the leading causes of disability having high prevalence in elderly population. There is a large debate regarding usage of biologicals in treatment of OA knee. The purpose of this study is to evaluate the efcacy and safety of intra articular PRP injection in treatment of OA knee. Materials and methods: 50 patients were enrolled in this prospective non-randomized study.10 patients were lost to follow up.40 patients and 55 knees were studied .All of them received 2 doses of 5ml intraarticular PRP injection 3 weeks apart. The WOMAC scores and VAS scores at baseline, 1month, 3months and 6 months follow up are compared. Results: Out of 40 patients 25 had unilateral 15 had bilateral symptomatic osteoarthritis knee. A total of 55 knees were studied. 9 patients were males and 31 were females with mean age of 55.65yrs and mean BMI of 29.2. According to KL grading 40 knees were grade 3 and 15 were grade 4.There is statistically signicant (p<0.001) decrease in VAS scores and improvement in WOMAC functional scores after 2 doses of PRP injections. No signicant adverse effects were observed. Conclusion: Intraarticular PRP injection is safe, well tolerated and effective in treatment of primary osteoarthritis. There is decrease in pain and improvement in functional outcome after 2 doses of PRP. More well designed RCT'S with large sample and long term follow up are required to establish long term effectiveness of PRP injections.
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