Abstract
BackgroundPostoperative cognitive dysfunction (POCD) is a common condition after general anesthesia (GA). Previous studies have reported that propofol can ameliorate the occurrence of such disorder. However, its results are still inconsistent. Therefore, this systematic review will assess the efficacy and safety of propofol on POCD after GA.MethodsLiterature sources will be sought from inception to the present in Cochrane Library, MEDLINE, EMBASE, PsycINFO, Web of Science, Scopus, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure for randomized controlled trials (RCTs) assessing the administration of propofol on POCD after GA. All searches will be carried out without limitations to language and publication status. Outcomes comprise of cognitive impairments changes, impairments in short-term memory, concentration, language comprehension, social integration, quality of life, and adverse events. Cochrane risk of bias tool will be utilized to assess study quality. We will evaluate the quality of evidence for each outcome using Grading of Recommendations Assessment, Development and Evaluation approach. A narrative synthesis or a meta-analysis will be undertaken as appropriate.DiscussionThis study will systematically and comprehensively search literature and integrate evidence on the efficacy and safety of propofol on POCD after GA. Our findings will be of interest to clinicians and health-related policy makers.Systematic review registrationPROSPERO CRD42020164096
Highlights
Postoperative cognitive dysfunction (POCD) is a common condition after general anesthesia (GA)
The occurrence of POCD is associated with surgical trauma and general anesthesia (GA) [9]
Propofol is commonly utilized as anesthesia with neuroprotective effect in clinical surgical settings [13,14,15], which cannot only reduce the incidence of POCD and can delay onset and shorten its duration in the elderly patients [16,17,18,19,20,21,22,23,24,25,26,27]
Summary
Study protocol registration This protocol has been registered on PROSPERO (CRD42020164096), and has been reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P) statement (Additional file 1) [28]. We will extract data by the form of study information (e.g., first author, title, country, year of publication, and sample size), patient characteristics (e.g., age, sex, and eligibility criteria), study setting, study quality (e.g., random sequence generation, allocation details, and blind), details of interventions and controls, outcome indicators, and any other relevant information. Risk of bias assessment Two authors will independently evaluate and cross check the risk of bias of RCTs using Cochrane risk of bias tool through selection, performance, detection, attrition, reporting, and other risk of bias [31]. If sufficient RCTs are available and variability across eligible trials is low, a meta-analysis will be performed according to the comparisons of different study information, patient characteristics, details of propofol and controls, and outcome indicator measurements. Amendments Any amendments to this protocol will be recorded with reference to saved searches and analysis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
