Abstract
Recent clinical studies have suggested that supplemental progesterone, (P4) may be effective at preventing preterm birth in high-risk women but the mechanism of action is unclear. We hypothesized that P4 enhances the ability of epithelial cells in the reproductive tract to detect and respond to pathogens before they can ascend into the upper genital tract. Many pathogens associated with preterm birth are recognized through TLR2 whose signal transduction pathways are negatively regulated by Tollip.
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