Abstract
BackgroundPrepectoral (PP) immediate implant-based breast reconstruction (IBBR) is becoming increasingly popular compared to retropectoral reconstruction (RP). This study compares the timing of different adjuvant therapies (ATs) administration after PP or RP IBBR. Patients and MethodsA monocentric retrospective analysis was conducted on patients undergoing mastectomy and IBBR from January 2018 to December 2023. Preoperative characteristics, mastectomy procedure type, PP or RR implant placement, postoperative outcomes, AT type, time between surgery and AT administration were collected and analyzed. Results167 patients (206 breasts) were included. 123 underwent PP IBBR and 44 RP IBBR. The mean time between surgery and first AT administration was similar in PP group (45.7 days, SD 39.3) compared to the RP group (37.4 days, SD 33.1) (p-value 0.2100). No significant differences were found in the timing of endocrine therapy (ET), chemotherapy (CT), or radiotherapy (RT) initiation between the PP and RP groups. Patients with seroma had a delayed initiation of CT (83.67 days, SD 123.7) versus those without seroma (42.1 days, SD 29.7) (p-value 0.0298). ConclusionsAverage time between surgery and administration of first AT following PP IBBR was similar compared to RP IBBR. Postoperative seromas were associated with delayed CT in overall population.
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