Abstract
Background: Infants with NAS may have disturbed sleep, and increased movement reflecting central nervous system irritability. However, sleep pattern in such infants following control of withdrawal symptoms with methadone hasn’t been quantitatively analyzed. We hypothesized that successful treatment of withdrawal symptoms with methadone would also improve the sleep patterns in infants with NAS. Persistent disordered sleep in the neonatal period if persists even after pharmacological control of withdrawal symptoms may potentially lead to adverse childhood neurodevelopmental outcome. Objective: To characterize sleep-wake states using Actigraphy (activity-based sleep-wake …
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