Does PCOS patients are good egg donors?

Abstract

Compare the pregnancy rates of egg receptors from donor patients diagnosed with polycystic ovarian syndrome (PCOS) to receptors from donors without ovarian pathology. Retrospective case-control observational study. Total of 234 patients undergone into egg reception program. Those patients were separated into two groups: Group I - Receptors from PCOS donors (N=36); Group II - Receptors from donors without ovary patologies (N=198). The PCOS patients were classified following the Rotterdan criteria. The medical records were reviewed and the following data were collected: age of donors and receptors; number of retrieved oocytes, number of mature oocytes (metaphase II) that were used by the receptors, the number of fertilized embryos on day 1. Fertilization, implantation and cumulative pregnancy rates were also calculated. Student T test were used to analyze the mean of the collected data between the groups and the Chi-square test was used to analyze the cumulative pregnancy, fertilization and implantation rates. The mean age for both receptors groups were similar, 42 years old. The PCOS donors had an average age of 30 years against 29 years of donors from Group II. There was no statistical difference. PCOS patients had an average of 3.23 more oocytes collected, but there were no difference of the number of mature oocytes that were used for donation between the groups. We also observed that the number of transferred embryos were also not significantly different, as well as the fertilization and implantation rates. The cumulative clinical pregnancy rates were not significantly different: 28% and 26% in Group I and Group II, respectively.Tabled 1Basal patients Characteristics and Characteristics of ovarian cyclesMeans value ± standart deviationPCOS Donors n = 36 Group INormal Ovarian Donors n = 198 Group IIp valueReceptor age42 (±5 SD)42 (±5 SD)0,92Donor age30 (±3,51 SD)29 (±3,49 SD)0,92Oocytes Retrieved (total)21,63 (±10,44 SD)18,40 (±8,21 SD)<0,05Mature oocytes used recipient7,39 (±2,92 SD)7,91 (±3,25 SD)0,37Day 1 embryos (2 pn)5,11 (±2,79 SD)5,21 (±2,85 SD)0,85Embryos Transferred2,65 (±0,96 SD)2,23 (±0,64 SD)0,56Implantation Rate (%)11 (7/61)13 (51/379)0,83Fertilization Rate (%)69 (184/266)67 (1032/1551)0,42cumulative pregnancy rate (%)28 (10/36)26 (51/199)0,79 Open table in a new tab The use of PCOS donors for egg donation programs did not affect the results of the receptor, therefore, women with PCOS should not be excluded from egg donation programs.