Does oral calcium intake or body habitus relate to the degree of valvular calcification and adverse events in patients with severe aortic stenosis?

Abstract

The safety of calcium supplements has drawn much controversy, especially since its use is becoming more prevalent. A recent meta-analysis shows that there is an increased risk of incident myocardial infarction in patients taking calcium [ [1] Bolland M. Avenell A. Baron J. et al. Effects of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010; 341: c3691 Crossref PubMed Scopus (850) Google Scholar ]. While calcium use appears to contribute to the risk of cardiovascular events, it does not seem to have an effect on aortic valve calcification (AVC). A study on patients taking calcium supplementation demonstrates that these subjects do not experience an accelerated rate of progression in AVC [ [2] Bhakta M. Bruce C. Messika-Zeitoun D. et al. Oral calcium supplements do not affect the progression of aortic valve calcification or coronary artery calcification. J. Am.Board Fam. Med. 2009; 22: 610-616 Crossref PubMed Scopus (24) Google Scholar ]. The relationship between body mass index (BMI) and cardiovascular events in aortic stenosis (AS) has also been well-established. It is found that in asymptomatic patients with AS, being overweight or obese does not influence AS progression or rate of AS-related or ischemic cardiovascular events but is associated with increased mortality [ [3] Rogge B. Cramariuc D. Lønnebakken M. et al. Effect of overweight and obesity on cardiovascular events in asymptomatic aortic stenosis: a SEAS substudy (Simvastatin Ezetimibe in Aortic Stenosis). J. Am. Coll. Cardiol. 2013; 62: 1683-1690 Abstract Full Text Full Text PDF PubMed Scopus (40) Google Scholar ]. Overall, there are limited studies examining the relationships between calcium use, BMI and cardiovascular events in patients with severe AS. Corrigendum to “Does oral calcium intake or body habitus relate to the degree of valvular calcification and adverse events in patients with severe aortic stenosis?” [Int. J. Cardiol. 180 (2015) 74–75]International Journal of CardiologyVol. 199PreviewWe sincerely apologize for the amendments caused and thank you very much for your help. Full-Text PDF Corrigendum to “Does oral calcium intake or body habitus relate to the degree of valvular calcification and adverse events in patients with severe aortic stenosis?” [Int. J. Cardiol. 180C (2014) 74–75]International Journal of CardiologyVol. 191PreviewThe authors regret for the error occurred in Table 2 and the corrected version is provided below. Full-Text PDF