Abstract

Off-pump coronary artery bypass surgery (OPCAB) has been hypothesised to be beneficial in the high-risk patient population undergoing re-operative coronary artery bypass graft surgery (CABG). In addition, this technique has been demonstrated to provide subtle benefits in end-organ function including heart, lungs and kidney. The aims of this study were to assess whether OPCAB is associated with a lower incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and other adverse outcomes in re-operative coronary surgery. Twelve studies, incorporating 3471 patients were identified by systematic literature review. These were meta-analysed using random-effects modelling. Primary endpoints were MACCE and other adverse outcomes including myocardial infarction, stroke, renal dysfunction, low cardiac output state, respiratory failure and atrial fibrillation. A significantly lower incidence of myocardial infarction, stroke, renal dysfunction, low cardiac output state, respiratory failure and atrial fibrillation was observed with OPCAB (OR 0.58; 95% CI (confidence interval) [0.39-0.87]; OR 0.37; 95% CI [0.17-0.79]; OR 0.39; 95% CI [0.24-0.63]; OR 0.14; 95% CI [0.04-0.56]; OR 0.36; 95% CI [0.24-0.54]; OR 0.41; 95% CI [0.22-0.77] respectively). Sub-group analysis using sample size, matching score and quality score was consistent with and reflected these significant findings. Off-pump coronary artery bypass grafting reduces peri-operative and short-term major adverse outcomes in patients undergoing re-operative surgery. Consequently we conclude that OPCAB provides superior organ protection and a safer outcome profile in re-operative CABG.

Highlights

  • The outcome profile of off-pump coronary artery bypass surgery (OPCAB) has received much attention and analysis

  • Whilst recent randomised trials have popularly failed to demonstrate the beneficial effects of OPCAB in comparison to on-pump coronary artery surgery (ONCAB) with regards to mortality and major adverse cardiovascular and cerebrovascular events (MACCE), subtle benefits in end-organ function have been observed [1,2]

  • The aim of this study is to address the question of whether OPCAB is associated with a lower incidence of MACCE and other adverse outcomes in re-operative coronary surgery

Read more

Summary

Introduction

The outcome profile of off-pump coronary artery bypass surgery (OPCAB) has received much attention and analysis. Whilst recent randomised trials have popularly failed to demonstrate the beneficial effects of OPCAB in comparison to on-pump coronary artery surgery (ONCAB) with regards to mortality and major adverse cardiovascular and cerebrovascular events (MACCE), subtle benefits in end-organ function have been observed [1,2]. The scepticism surrounding the external validity of these trials, regarding selective patient enrolment and individual surgeon’s OPCAB experience still remains [3], and has heralded the need for closer analysis of registry data, providing a closer ‘reallife’ representation of the population [4,5]. The aim of this study is to address the question of whether OPCAB is associated with a lower incidence of MACCE and other adverse outcomes in re-operative coronary surgery.

Objectives
Methods
Results
Conclusion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call