Abstract
The prototype environmental neurotoxin, 2,5-hexanedione(2,5-HD), induces changes in somata of sensory ganglia that are morphologically similar to chromatolysis; this study assessed the functional significance of neuronal alterations. Experimental rats were exposed 6 weeks to 2,5-HD, and after 1 week without treatment were then subjected to experimental crush of the sciatic nerve (paired controls were unintoxicated). Nerve regeneration was assayed by the pinch test 4 to 13 days after crush. These preliminary results did not show an accelerated rate of axonal outgrowth; however, there was a small but significant ( P < 0.05) decrease in the initial delay.
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