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Abstract
Aim: TRIB1 is a pseudokinase and recent GWAS analyses have linked this gene to the control of lipid homeostasis. Analysis of full body TRIB1 knockout and a liver specific TRIB1 overexpressing mouse have demonstrated that hepatic expression of TRIB1 reduces VLDL production, plasma triglycerides and cholesterol. Additionally, TRIB1 has been shown to be necessary for the development of M2 tissue macrophages. However, the interplay between TRIB1, macrophages and hepatocytes is unexplored.
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