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Abstract
Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent. In the present study, we conducted a meta-analysis to sniff out the potential risk between miR-618 rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z-test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet the enrolled criteria, along with 4099 cancer cases and 5057 healthy controls. Overall, no exceeding interrelation was sniffed out in the pooled data among five inherited models, as well as stratified analyses. Whereas, the enhanced cancer risk of miR-618 rs2682818 variant stratified by breast cancer was revealed, in heterozygote genetic model (AC vs. CC: OR = 1.291, 95%CI = 1.012–1.648, P = 0.040) and dominant contrast model (AA + AC vs. CC: OR = 1.280, 95%CI = 1.009–1.623, P = 0.042). The second structure prediction result shown that the mutant A allele might change the first stem-loop of miR-618, and the free energy of it would turn from –39.1 to –35.1 kcal/mol. All in all, our meta-analysis had successfully chased down that miR-618 rs2682818 polymorphism is not linked with overall cancer risk, but in the dominant genotype of breast cancer.
Highlights
MicroRNAs, a series of 17–25 length small nucleotides, have been widely studied about its function in several types of cancer
Ivanovic et al [30] found out that the overexpression of miR-618 could suppress the function of MMP-9 to prevent the progress of tumorigenesis, on the other hand, they obtained the links that the expression level of miR-618 is negatively associated with the high Gleason score and advanced stages
Shi et al [31] revealed that the expression level of miR-618 in gastric cancer tissues is down-regulated compared with the adjacent non-tumor tissues, while overexpression of miR-618 could suppress the migration and invasion capacity of gastric cells
Summary
MicroRNAs (miRNAs), a series of 17–25 length small nucleotides, have been widely studied about its function in several types of cancer. The method of miRNA expression profiling has been applied to reveal whether it promotes or suppresses tumorigenesis, and exposed to be the biomarkers of predicting the occurrence or prognosis of tumors [1,2,3,4,5]. The size and number of miRNAs are less than messenger RNAs (mRNAs), they play a pivotal role in the regulation of mRNAs through binding to the 3 -UTRs of mRNA, affect the expression and function of tumor associate genes [6,7,8]. Whether rs2682818 polymorphism of miR-618 is associated with cancer susceptibility, we planned to verify and obtain the precise result in the current study
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